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Zhenjie Tang, [email protected] This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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5 Potential role of ferroptosis in RA inflammation and tissue damage 5.1 Ferroptosis products and derivatives can act as inflammatory mediators Ferroptosis is an immunogenic form of cell death, and its metabolites and derivatives can also act as inflammatory mediators to further exacerbate RA inflammatory responses