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The Pro-Gly-Pro (PGP) addition is a stabilising motif that protects against enzymatic degradation and increases half-life

Mounting an antioxidant response may entail costs (e.g., energetic, nutrients for enzyme synthesis, production of enzymatic co-factors), which implies that factors such as the environmental conditions animals live in might play an important role in mediating an organisms response to the infection

References usually state the safe amount of drug in mg per kg for a 24-hour period to be given in one or more divided doses

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