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In some cases long before symptoms occur

Effect of frequent consumption of a Lactobacillus casei-containing milk drink in Helicobacter pylori-colonized subjects

This increase in bioavailability of N-3 PUFAs could lead to a more anti-inflammatory environment [189] in these brain regions, potentially modulating microglia

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Inhibition of the action of the GTPase involved in mitochondrial fission dynamin-related protein 1 (DRP1) and reduced levels of mitochondrial metabolic proteins lead to many neurodegenerative diseases through the accumulation of misfolded TAU proteins called tauopathies. Normally, TAU is responsible for microtubule attachment and cytoskeleton stability in the brain (Petrozziello et al., 2022)

A simplified schematic representation of the molecular and physiological pathways influenced by the main supplements reviewed