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and (2) plus Dox (1 g ml 1 final concentration) to induce the shRNA targeting MYCN (IMR5/75 low MYCN )

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Additional studies using other synthetic analogs of PregS revealed that a negatively charged moiety at the C3 position is, however, essential for positive modulation of NMDARs ( 2+ ([Ca 2+ ]i)-dependent and non-canonical mechanism involving G-proteins (Figure 2)

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