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The size distribution was between 50 and 90 nm in diameter

doi: 10.2147/DDDT.S364441 53 QiKLiJHuYQiaoYMuY

Plasmo GEM barcodes were amplified by PCR in using the extracted DNA samples and the primers 91_Illumina and 97_Illumina (Source data file)

Glossary AD Alzheimer's disease PD Parkinson's disease ALS amyotrophic lateral sclerosis HD Huntington's disease ROS Reactive oxygen species TRF transferrin TfR1 transferrin receptor 1 NCOA4 nuclear receptor coactivator 4 HSP90 heat-shock protein 90 IL-1 interleukin 1 IL-18 interleukin 18 GZMA proteins human granzyme family members GSDMB Gasdermin structural domain protein family member IFN- gamma interferon SLC7A11 solute carrier family 7 member 11 GSH glutathione PUFAs polyunsaturated fatty acids ALOX arachidonic acid lipoxygenase AA arachidonic acid AdA adrenoic acid PE phosphatidylethanolamine ACSL4 acetyl coenzyme a synthetase long-chain family 4 LPCAT3 lysophosphatidylcholine acyltransferase 3 CPY450 cytochrome P450 oxidoreductase hephaestin ferrous oxidase TFR1 transferrin receptor 1 STEAP3 prostate hexagonal transmembrane epithelial antigen 3 DMT1 divalent metal transporter protein 1 NCOA4 nuclear receptor coactivator 4 FPN1 iron transporter protein 1 CP Ceruloplasmin RSL3 GSH peroxidase 4 inhibitor HO-1 heme oxygenase-1 NRF2 nuclear factor erythrocyte 2-related factor 2 PLOOH phospholipid hydroperoxides MDA malondialdehyde 4-HNE 4-hydroxynonenal GPX4 glutathione peroxidase 4 PCBP1 chaperonin poly(rC)-binding protein 1 ACSL4 acyl coenzyme a synthase long-chain family member 4 LPCAT3 lysophosphatidylcholine acyltransferase 3 PTGS2 Prostaglandin peroxidase synthase 2 PPAR peroxisome proliferator-activated receptor OS Oxidative stress NADPH nicotinamide adenine dinucleotide phosphate NOX NADPH oxidase XO xanthine oxidase DPP4 dipeptidyl peptidase 4 VDAC voltage-dependent anion channel PLs phospholipids CoQ10 coenzyme Q10 GCL Glutamate cysteine ligase BSO L-buthionine sulfoximine TBH t-butyl hydroperoxide Fer-1 Ferrostatin-1 Lip-1 Liproxstatin-1 SOD1 Superoxide dismutase 1 ETC electron transport chain MGST1 Microsomal glutathione S-transferase 1 STING1 Stimulator Of Interferon Response CGAMP Interactor 1 ESCRT-III Endosomal Sorting and Transport Complex-III ER endoplasmic reticulum GSS glutathione synthetase Sec selenocysteine MVA mevalonate SAS Sulfasalazine DHODH Dihydroorotic acid dehydrogenase GCH1 GTP Cyclic Hydrolyserase 1 BH4 Tetrahydrobiopterin Keap1 kelch-like ech-related protein1 AREs antioxidant response elements HCC hepatocellular carcinoma cGAS-STING (cGAMP) synthase-interferon gene-stimulating factor dsDNA double-stranded DNA TBK1 tank-binding kinase1 IFN interferon IRF3 interferon regulatory factor3 ISGs IFN-stimulated genes MFN mitofusin gene DHA docosahexaenoic acid DFO Deferoxamine HIF1 Hypoxia-inducible factor 1 APP amyloid precursor protein APP apolipoprotein E PSEN1 progerin1 PSEN2 progerin2 A Amyloid beta NFTs neurofibrillary tangles MRI magnetic resonance imaging DFP deferiprone BACE1 beta-site amyloid precursor cleaving enzyme-1 TNF tumor necrosis factor MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine DA dopamine 6-OHDA 6-hydroxydopamine APP-/- APP knockout mouse model SN substantia nigra LB(s) Lewy bodies D-PUFAs Deuterated polyunsaturated fatty acids DA 3-hydroxytyramine Cu(II)ATSM a positron emission tomography developer sensitive to hypoxia MPP+ 1-methyl-4-phenylpyridinium HTT Huntington's protein mHtt mutant Htt 3-NP 3-nitropropionic acid GST glutathione S-transferase HSP27 Heat shock protein 27 CNS central nervous system SOD1 Superoxide dismutase1 GPX 4 NIKO GPX 4 neuron induced knockout

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