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The upregulation of glycolytic enzymesincluding glyceraldehyde-3-phosphate dehydrogenase (GAPDH), pyruvate kinase M1/2 (PKM), and lactate dehydrogenase B (LDHB)has been observed [23]

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Cys 2 ), cystine-free (Cys 2 -free), cystine-free/L-NAC-supplemented (400 M), cystine-free/D-NAC-supplemented (400 M) medium, untreated or treated with BSO (100 M) for 72 h, and relative cell numbers were determined (n = 4 technical replicates)

Figure 3 Tumor hypoxia is well recognized in oncology as a major cause of therapy resistance and poor prognosis