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The lack of interactions of P37 Cagri with RAMP 1 and 3 is consistent with the ability of Cagri to form high-affinity interactions with the CTR protomer alone (Fig

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Current conventional chemotherapeutics, unfortunately, are not specialized for malignant cells and because such therapeutics do not present selective mechanisms to detect normal/abnormal cellular dividing rates, they have severe side effects such as alopecia, vomiting, rashes, and, in some cases, myelosuppression on other cells and organs throughout the body