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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

This overstimulation results in increased intracellular calcium levels, leading to neuronal injury and apoptosis ( Postmortem examination of patients with chronic epilepsy reveals a noticeable atrophy of cerebellar Purkinje cells (Yardmoglu et al., 2007)

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The p62-Keap1-NRF2 pathway NRF2 is a stress-inducible transcription factor

However, pathogens can evolve effectors to suppress PTI, leading to effector-triggered susceptibility (ETS)

While the effect of diet and environmental exposures on the human microbiome and the implications of these changes on the host immune and inflammatory systems have been explored in AMD 115 , to gain a complete understanding of the complex interactions and their role in the pathogenesis and progression of dry AMD, all individual perturbations must be integrated into the entire system to establish a causal role