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10 White-coat hypertension, however, has been associated with functional and structural cardiovascular abnormalities, including reduced arterial elasticity, left ventricular diastolic dysfunction, and enlarged arteries, similar to persistent hypertension

I first heard of it through functional medicine practitioner and cofounder of Function Health Mark Hyman, MD, but its been around over 40 yearsand for good reason

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Consistently, immunofluorescence analysis suggested a reduction in IBA1 immunoreactivity in the hippocampus following WEH treatment (Figure 6G), while GFAP expression remained largely unchanged (Figure 6H)

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The range of possible values that treatment effectiveness can take can be sufficiently wide that it is no longer possible to determine whether the treatment has a positive or negative causal effect