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Here, microbiome-derived short-chain fatty acids (SCFAs) and anti-inflammatory metabolites can suppress NLRP3 activity by inhibiting ROS production and modulating histone acetylation, promoting tissue homeostasis [31]

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Chem 87 (2015) 1118711194

However, it was not ruled out that tubular cell death might have occurred secondary to some changes outside the tubular compartment: e.g., in RIPK3-dependent organ perfusion, which might be altered also upon Nec-1 treatment if the necroptotic pathway was involved