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These conditions often induce structural changes in the atria, such as atrial enlargement, increased fibrosis, elevated epicardial adipose tissue, autonomic nervous system dysfunction, systemic inflammation, impaired myocardial contractile function, and alterations in myocardial cell structure (Vlachos et al., 2016)

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In contrast, TdfJ, similar to TdfH, allows bacteria to accumulate zinc, but in this case, zinc uptake is not allowed if zinc is associated with calprotectin (Jean et al., 2016), and was therefore renamed ZnuD (Kumar et al., 2012

These findings are consistent with the previously shown beneficial therapeutic effects of DMF in hypoxia and SU5416/hypoxia mouse models of PH 49

doi:10.1142/s0192415x98000415 Hijikata Y, Yamada S, Yasuhara A

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