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All-cause admissions following a first ever exacerbation-related hospitalization in COPD

The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment

Therefore, HDAC6-specific overexpression in AAV8-mediated gene delivery of LSECs may represent an innovative therapeutic strategy for ALD

Although this region of the enzyme has been confirmed to bind GSH and the C28-C31 pair has been observed to be necessary for the reduction of GSSG, there is no explicit evidence of how electrons are transmitted to the GR domain

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

Mechanistically, NAMPT can also regulate stemness in a paracrine manner through the senescence-associated secretory phenotype