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The value is adjunctive: they prevent hepatic fat accumulation during aggressive calorie restriction, and they correct B12 deficiency that would otherwise limit exercise capacity and metabolic rate

Tanida Y, Matsuura A (2020) Alchemical free energy calculations via metadynamics: application to the theophylline-RNA aptamer complex

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Tirzepatide at its highest dose (15 mg) produced 22.5% weight loss in the SURMOUNT-1 trial (N=2,539) at 72 weeks [8]

Improves Mood : Plays a role in serotonin production, potentially improving mood