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The FDA label (NDA 021446) lists the following key pharmacokinetic parameters: oral bioavailability greater than 90%, linear pharmacokinetics up to 600 mg/day, renal elimination as unchanged drug (greater than 98%), and no meaningful hepatic CYP metabolism [4]

doi: 10.1016/J.MSET.2018.12.001 144

Labs were notable for TB 20.6 mg/dL, DB 16.6 mg/dL, sBA 222.2 umol/L, TG 252 mg/dL, cholesterol 303 mg/dL, HDL cholesterol 15 mg/dL, LDL cholesterol 237 mg/dL

Quantitative analysis via the IVIS system revealed that the degree of tumor accumulation in the DiR/AAP NPs group was approximately 1.7-fold greater than that in the DiR/ART-Ala NPs group at 60 h postinjection

2016;11:e0163571