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In preparing this review, we selected the most robust and relevant preclinical data to illustrate the therapeutic promise of natural products

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A lot of research on the presence of microplastic in the environment and their consequences on marine species, in terms of physical harm, behavioral changes, tissue lesions, oxidative stress, and gene damage, has been conducted in recent years ( Several studies have documented that aquatic ecosystems across the world have been polluted with microplastic (Zhu et al., 2018

In conclusion, HIF might promote mitophagy induction in hypoxia by transcriptionally activating the mitophagy factors BNIP3 and BNIP3L

Aquat Toxicol 62:219226 Biswas SK, Rahman I (2009) Environmental toxicity, redox signaling and lung inflammation: the role of glutathione

The data acquired using multiple omics platforms may be evaluated individually in each omics dataset to discover biomarkers, or multiple omics datasets can be integrated to obtain a more comprehensive systems biology biomarker of the drug-induced hepatotoxicity (Ilyin et al