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Effects of Adderall Common side effects associated with Adderall use include the following: Constipation or diarrhea Headache Dry mouth Nervousness Nausea Loss of appetite and weight More severe side effects may include the following: Seizures Hallucinations Mania Swelling of the face Itching, rashes, and hives Numbness or tingling Paranoia or feelings of suspicion Agitation and confusion Fever and sweating or chills Severe muscle stiffness or twitching Impaired coordination Nausea and vomiting Diarrhea Difficulty breathing Dizziness Depression Blistering or peeling skin Weakness and fatigue Changes in vision Slow or difficult speech Motor or verbal tics Teeth grinding About Marijuana Marijuana is considered to be a relatively safe substance compared to many others, such as alcohol or opioids