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Tregs are responsible for maintaining immune homeostasis by suppressing overactive immune responses, preventing autoimmune reactions, and ensuring tolerance to self-antigens [321]

In a noncytotoxic manner, formononetin decreased IgE expression by PBMCs dose-dependently (20, 10, 5, and 2.5 g/mL) [121]

Zamorano P, Koning T, Oyanadel C, Mardones GA, Ehrenfeld P, Boric MP, Gonzlez A, Soza A, Snchez FA

Characterized by abundant regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and M2-polarized tumor-associated macrophages (TAMs), all of which inhibit antigen presentation and effector T-cell function