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[133] reported a randomized, controlled, single-blind, intra-patient left- to right-side trial comparing the efficacy and safety of vitamin B 12 -containing ointment (0.07% cyanocobalamin in a w/o formulation with 20% avocado oil) (M-treatment) with a glycerol-petrolatum-based emollient cream (C-treatment) in 24 patients with mild-to-moderate plaque psoriasis for a period over 12 weeks followed by a wash-out observation period of 4 weeks

Drug-induced liver toxicity accounts for nearly half the cases of acute liver failure in adults over age 50 in the United States [3] and most have been associated with the generation of reactive metabolites, which are primarily detoxified via glutathione conjugation [4]