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Given that GPR146 is most highly expressed in mature adipocytes, obesity-associated changes such as increased immune infiltration and stromal remodeling may reduce the relative abundance of GPR146-expressing cells in bulk tissue profiles

A significant study involving rats exposed to ACR at a dosage of 50 mg/kg for 11 days revealed notable increases in critical oxidative stress markers, including malondialdehyde (MDA) and nitric oxide

In addition to transcription factors mentioned above, there are also some other mechanisms involved in sorafenib resistance

DOI: 10.1016/j.molmet.2018.02.006

[10] Native amylin is chemically unstable and short-lived, which makes it impractical as a once-weekly drug

Xu B, Sai N, Gilliham M (2021b) The emerging role of GABA as a transport regulator and physiological signal