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It takes four half-lives for concentrations to drop from an effect of 80% to 20% of E max 15% of the effect is lost every half-life over this concentration range

Yet, a one-year placebo-controlled, double-blind trial that provided ten times the recommendation of nine vitamins was carried out in 127 healthy young adults (aged 17-27 years) (103)

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Therefore, if there is vitamin B12 deficiency, then most folate forms in the body are trappeD as 5-Methyl-tetrahydrofolate form causing homocysteine imbalances

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