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In addition, this AOP can inform on the identifications of in vitro methods that can be developed for an integrated approach to testing and assessment (IATA) based on in vitro neurotoxicity assays complementary to in vivo assays

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Each mechanism of dysfunction at the pre-synaptic, post-synaptic, and peri-synaptic level offers itself as a target for intervention to improve stabilization, junctional signaling, and synapse integrity [213], potentially even before symptomatic weakness in those with genetic susceptibilities

AMP-activated protein kinase phosphorylation of endothelial NO synthase

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