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SOD and CAT function collaboratively to mitigate redox imbalances The level of O 2 in cells is regulated by its conversion to HO through the activity of SOD

While CBP/p300 is a well-validated direct interaction partner of NRF2 with prominent functions at enhancers, we report that this interaction is not required for NRF2-dependent NSCLC cell growth, indicating that NRF2 can sustain sufficient transcriptional activity in the absence of CBP/p300 coactivation