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784 F-1,6-BP also induces the expression of apoptotic proteins, facilitating apoptosis in liver cancer cells

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PC also converts pyruvate to oxaloacetate that can be used to replenish the TCA cycle or for the initiation of gluconeogenesis (in liver and kidney) or lipogenesis (adipose tissue, liver as well as brain) [107]

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There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

Milk, which is rich in Vitamin D, helps fade dark spots and tan