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Lee KA, Baker FC

In the tumor microenvironment, chronic oxidative stress promotes PD-L1 upregulation and T cell exhaustion, while localized low levels of ROS may enhance angiogenesis via HIF-1 signaling

Likewise, systemic inflammation and glucocorticoids can also cross the BBB and influence the formation of QA in the brain by the microglia and infiltrated macrophages, enhancing the neuroinflammatory cascade [224]