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Notably, mitochondria are considered one of the major producers of ROS, especially in the production of mitochondrial H 2 O 2

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Such findings are in alignment with longer history of liver injury and more advanced fibrosis in T2DM patients and show the limitations of using scores for patient's risk stratification

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In contrast, normal and healthy cells metabolize glucose via glycolysis into pyruvate, which is then sent to the tricarboxylic acid cycle (TAC) to generate a large amount of ATP molecules via oxidative phosphorylation (134)