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Lei XW, Li Q, Zhang JZ, Zhang YM, Liu Y, Yang KH

There have been efforts to overcome these problems by modifying the drugs in different ways to circumvent these hindrance such as (1) isolate human native enzymes to reduce allergy, (2) isolate enzyme isoforms with higher specificities and efficiencies, (3) pegylate the enzymes to reduce allergy and prolong the half-lives, and (4) design drug combinations protocols to enhance the efficacy of chemotherapy by drug synergy and minimizing resistance

When used on the scalp, scientists suggest it stimulates the hair follicle size, improves blood circulation, and reduces inflammation

The translational gap between preclinical findings and clinical outcomes underscores the need for more rigorous study designs that account for bioavailability, participant heterogeneity, and methodological inconsistencies

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Zhao W, Zhou S, Yao W, Gan X, Su G, Yuan D