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Xiaoyu Zhao: Investigation, Visualization

& Deacon, C

(2019) Mechanisms of ferroptosis and relations with regulated cell death: A review, Front Physiol

In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels