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Furthermore, a different approach using intragastrically administered rotenone (5 mg/Kg) in mice showed that the accumulation and aggregation of -synuclein in neurons of the dorsal motor nucleus of the vagus (DMV) and the intermediolateral nucleus (IML) in the spinal cord was accompanied by the selective loss of dopaminergic neurons and astrogliosis, suggesting that the gastric administration of rotenone through the connection of the enteric nervous system (ENS) with anatomical structures of the CNS also induces PD-like features [11,19]

Gahete MD, Cordoba-Chacn J, Duran-Prado M, Malagn MM, Martinez-Fuentes AJ, Gracia-Navarro F, Luque RM, Castao JP (July 2010)

Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy