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Kim JE, Kim HS (2019) Microbiome of the skin and gut in atopic dermatitis (AD): understanding the pathophysiology and finding novel management strategies

Damage-associated molecular patterns (DAMPs) released by injured neurons, such as pathological proteins, extracellular ATP, and high mobility group box 1 protein (HMGB1), can activate pattern recognition receptors on the glial cell surface, triggering neuroinflammation ( In conclusion, neuroinflammation serves as a critical bridge connecting peripheral pathology and central symptoms in MG, while age-related factors significantly influence MG onset and progression through immunosenescence, neuromuscular junction degeneration, and activation of the neuroinflammation-oxidative stress-mitochondrial dysfunction axis