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The European Association for the Study of the Liver (EASL) and NICE both emphasise that lifestyle modificationincluding weight loss, dietary improvement, and increased physical activityremains the cornerstone of NAFLD management, with antioxidant supplementation playing at most an adjunctive role in carefully selected cases under specialist supervision

Few studies have documented that CYP2E1 activity was higher in males compared to females, resulting in 30% higher clearance of ethanol and chlorzoxazone (Lucas et al

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Two molecules that have been recently involved in oxidative damage and inflammatory response are Nitric oxide (NO) and Carbon monoxide (CO)

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To distinguish between monomeric and assembled states, we determined the critical aggregation concentrations of compounds 1 and 2 to be 59.4 M and 114.7 M, respectively (Supplementary Fig