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Importantly, the age at onset has shifted downward, with the majority of patients developing symptoms during childhood or adolescence [6]

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Besides, the surface protein CD38 can enhance intracellular Ca 2+ levels to promote RasGRP2/Rap1-mediated CLL cell adhesion and migration [76, 77]

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doi: 10.1016/J.BBRC.2018.05.209 4 AkiraS

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This is exactly what has happened in the ME/CFS literature, where many different kit manufacturers have been used (see Table A1)

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This works if you want everything in one session, but the AM/PM split is cleaner and removes any interaction questions

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