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Brady M C, Stott D, Weir C J et al

As a long-term consequence of ligature-induced periodontitis, not only tissue gingival inflammation measured by extravasation increased but there was also a considerable bone loss in the periodontium

This excess histamine can trigger a wide range of symptoms, including skin flushing, hives, digestive upset, brain fog, and anxiety

This marks the transition into the final stage, where things get much worse

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In a 2013 review, the authors state theres substantial evidence for pterostilbenes preventive and therapeutic properties with regard to neurological, cardiovascular, metabolic, and hematologic health.48 The same review cites 20mg/kg as the lowest effective dose to achieve such benefits in rats,48 and an equivalent dose for an 80kg (176lb) human would be almost 260mg