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Additionally, ROS-driven dysregulation of microRNAs (miRNAs), including miR-23a, miR-141, and miR-132, has been linked to inhibition of antioxidant enzymes, further compromising redox homeostasis [89, 90]

Figure 2 Animal experiments have demonstrated that acute tryptophan depletion reduces brain tryptophan concentration by 70%, leading to decreased serotonin levels, diminished 5-HT receptor binding (236, 237), and effects on compulsive behavior (238)

Reversal of long-term dendritic spine alterations in Alzheimer disease models

Important Note : These findings are restricted to non-clinical, preclinical research

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doi: 10.1300/J092v14n02_04 35 Falk HvidbergMBrinthLSOlesenAVPetersenKDEhlersL