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The -glucan, lentinan, is a bioactive compound produced by the macrofungus, Lentinus edodes, and has been found to have potential in improving the side effects of broad-spectrum antibiotic consumption

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AOD-9604 has weak efficacy data

Preclinical toxicology studies in animals showed no concerning findings with chronic administration, but human long-term data would strengthen confidence in extended protocols

309,315 Therapies targeting endothelial function are being explored to prevent or mitigate DPN progression (Fig

Due to its limited bioavailability, TQ has only been the subject of two phase 1 clinical investigations