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Schenning KJ, Noguchi KK, Martin LD, Manzella FM, Cabrera OH, Dissen GA, Brambrink AM

44 The zinc wave originates in the perinuclear region, including the ER, and depends on calcium influx and MEK activation

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(77) found that melatonin (MT) restores redox balance by activating SIRT6, which in turn upregulates GPX4 and inhibits NCOA4-mediated ferroptosis, ultimately delaying cataract progression