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Advanced programmed NP systems for theranostic delivery across the BBB are often conceptualized as nanorobots or nanobots, as they are engineered to perform specific functions with controlled navigation and targeted action (184)

Lokker N A, Mark M R, Luis E A, Bennett G L, Robbins K A, Baker J B and Godowski P J (1992) Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding

Cells 96, 341352

doi: 10.1038/s41586-025-08940-0 65 HuJ

The ANLS model propose a metabolic compartmentalization in physiological conditions with predominance of glycolysis in astrocytes and oxidative metabolism of lactate in neurons (Magistretti and Allaman, 2015)

(A,E) Lower face width (mm) assessed by Visia 7 (cross-polarized light) showing facial contour changes over time