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The concentration of hemoglobin-bound CO (CO-Hb) is intermittently higher in the blood of smokers compared to non-smokers, at levels usually below 10% that are well below those typically associated with the well-documented clinical or epidemiological toxicity of CO 7,8,9

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The BPRF can be interpreted as indicating that, even accounting for between-study heterogeneity and its uncertainty, the log(RR) across the studied smoking range is at least as high as the BPRF (or at least as low as the BPRF for a protective risk)

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