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Under the often hypoxic and nutrient-deprived conditions of the TME, lipid metabolic reprogramming provides cancer cells with critical metabolic flexibility

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Through directly neutralizing the free radicals, regenerating other endogenous antioxidants (such as glutathione, vitamins C and E, and coenzyme Q10), and chelating the redox-active metal ions (e.g., Fe 2+ ), ALA could mitigate the Fenton reaction-mediated oxidative damage, thereby amplifying its powerful anti-oxidative activity (1315)

Glutamate and glutamine are two types of amino acids our bodies produce

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