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The cells of the AF are specifically derived from a population of Scleraxis ( Scx )+/SRY-related HMG-box ( Sox )9+ progenitors that are originally unorganized but eventually align into the lamellar pattern as determined by actin stress fiber networks (Hayes et al., 1999

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In particular, the irregular activation of the HGF/c-MET pathway enhances the survival of glioma cells via PI3K signaling [11], augments the spread of squamous cell carcinoma through STAT3 signaling [12], promotes the attachment of lymphoma cells via PI3K signaling [13], boosts the growth of head and neck squamous cell carcinoma (HNSCC) through MAPK signaling [14], and triggers EMT and invasion in prostate cancer through Erk/MAPK signaling [15]