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NF-B activity is mediated by numerous signaling pathways such as mitogen-activated protein kinases (MAPKs) and IB kinase (IKK)

Free Radic Biol Med 133:144152 Imai H, Matsuoka M, Kumagai T, Sakamoto T, Koumura T (2017) Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis

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Experimental data showed that 10 M resveratrol completely inhibited the release of the inflammatory mediator IL-6, while resveratrol-3-sulfate and resveratrol-disulfate decreased by 84.2 29.4% and 52.3 39.5%, respectively, and the release of TNF- was reduced by 48.1 15.4%, 33.0 10.0%, and 46.7 8.7%, respectively, in macrophage assays in vitro 60

Binding of ZEA and its derivatives initiate a sequence of events known to follow estrogen stimulation of target organs [127, 128]

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