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As early as 2009, Shankar had proposed that mitochondria released from necrotic cells activated NLRP3 inflammasome, but the process was inhibited by respiratory chain inhibitors such as rotenone

Extracorporeal treatment for acetaminophen poisoning: recommendations from the EXTRIP workgroup

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Mark Hyman : Theres another study, for example, where they looked at fatty liver, and different effects of differential fats calorie-for-calorie on fatty liver, and they found that the fats from PUFAs, from Omega-6 PUFAs, they caused acceleration of liver damage and inflammation

doi: 10.1038/aps.2012.83 95 TsayJYangZRossFPCunningham-RundlesSLinHColemanRet al

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