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The requirement for increased nAb concentration to inhibit cellcell spread may be associated with avidity effects of extended cell surfaces interacting with one another (in contrast to a viral surface with potentially less available surface for interaction), although other factors such as the restricted access of nAbs to interacting cell surfaces could also contribute 74,75

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Although the mean residence time of the slow-release preparation was significantly longer by 1 to 2 hours than that of the regular preparation in dogs, the clinical significance of this difference is questionable

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However, subsequent studies reported no significant differences in systemic oxidative stress biomarkers or brain GSH levels compared to placebo (Mischley et al