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How to interpret the labs Topical and systemic exposure contexts should not be treated the same

Immunity (2018) 48:102945.e5

Due to the compounds plasma half-life of approximately 3.86.9 hours [5] , twice-daily (BID) dosing may provide more sustained NNMT inhibition

(Source) When this enzyme is present in great concentration within fat cells and is highly expressed, obesity is inevitable: In the study by Kannt and colleagues, NNMT expression is increased ~2-fold in subcutaneous and omental adipose tissue of type 2 diabetic subjects (men and women), compared to healthy controls Importantly, interventions that increase insulin sensitivity, such as exercise and bariatric surgery, also decreased expression of NNMT in adipose tissue For this reason alone, scientists have been interested in every possible method for inhibiting NNMT expression: We report that NNMT expression is increased in [white adipose tissue (WAT)] and liver of obese and diabetic mice