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Differential aspartate usage identifies a subset of cancer cells particularly dependent on OGDH

The assessment of results was made at 24 and 96 hours after peptide administration and included changes in the kidneys on a scale from 0 to 3, where: 0 - healthy kidney, 1 - mild hydronephrosis, 2 - moderate hydronephrosis, visible dilation of the renal pelvis, few changes on the kidney surface, 3 - severe hydronephrosis, dilation of the renal pelvis, thinning of the renal parenchyma, and a significant number of changes on the kidney surface

Ullah R, Jo MH, Riaz M, Alam SI, Saeed K, Ali W, et al

& Zhou, H

S.ForlenzaO

Glutathione analogues fail to function as efficient inhibitors of the human ChaC1 enzyme Since active site inhibitor compounds often resemble the structure of the natural substrate, we decided to explore the possibility of -glutamyl tri peptides blocking the active site and acting as potential inhibitors for the human ChaC1 enzyme