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People with MEN-2 are not prescribed weight-loss injections for the same reason as the family-history exclusion above

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Frequently Asked Questions About B12 Shots Q: How often should I get Vitamin B12 injections

Severe or persistent symptoms may require medical attention and should be reported to your healthcare provider. Patients with certain health conditions or on specific medications should always talk with their healthcare provider before starting B12 injections to avoid interactions and ensure the treatment is appropriate

This skin darkening is generally reversible with the help of B12 shots

[2] If symptoms are severe or persistent, it's important to discuss them with your healthcare professional