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Similarly, Trx1 suppressed NLRP3 inflammasome activation and pro-IL1 production by inhibiting the IRE1 signaling pathway-mediated ER stress, thereby attenuating cellular ROS generation and mitigating the inflammatory response [131]

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10.1101/cshperspect.a028480 2 AnwarS

a temperature-compromised vial is not less effective, it is inert

Lian BL, Wu MF, Feng ZQ, et al

Figure 2 The NMDA and AMPA glutamate receptors regulate various calcium-, sodium-, and potassium-dependent intracellular pathways