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Knockdown of endogenous GPX4 or blockade of GPX4 using a specific inhibitor enhanced the chemosensitivity of EBV-infected NPC cells

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In glioblastoma, PHGDH binds to and stabilizes the transcription factor FOXM1, sustaining the expression of downstream targets (e.g., VEGF, CCND1, CHK2, and MMP-2 ) to drive glioma cell proliferation, invasion, and tumorigenicity [113] (Fig

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Elevated ATF3 expression in aging osteocytes promotes iron uptake by upregulating TFR1 while inhibiting SLC7A11-mediated cystine uptake, leading to iron overload and lipid peroxidation, ultimately resulting in ferroptosis

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