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There are three groups of people who should ensure they have a regular, reliable source of vitamin B12 by supplementing their diet with vitamin B12-fortified foods or B12 supplements: those whove had bariatric surgery (which can sometimes impair absorption), those eating plant-based diets, and the more than a hundred million Americans older than age 50

Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route

The Phase 2b trial used subcutaneous injection, not oral formulation

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Studies also show it upregulates genes linked to healing and downregulates those associated with damaging inflammation [2]