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However, not only does p62 prevent NRF2 binding to KEAP1, it induces autophagic degradation of KEAP1, resulting in a positive feedback loop of NRF2 activation [82]

Tertiary amine modification enables triterpene nanoparticles to target the mitochondria and treat glioblastoma via pyroptosis induction

Reactive metabolites (such as ROS and electrophiles) can promote adaptive responses through mitochondrial dysfunction, endoplasmic reticulum stress, or DNA damage, thereby increasing molecular chaperone proteins (Figure 3)

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However, some nanodrug carriers with diameters of 1100 nm have greater therapeutic and diagnostic significance for GBM[56] (Fig