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Vial presentations often serve the need for early clinical studies, as the dose volume can be easily adjusted for dose escalation and the development of vial presentations is less complex than for injection devices, making it less prone to technical issues that might lead to a delay of FIH clinical trials

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USA 101 , 46374642 (2004)

Preda A, Montecucco F, Carbone F, et al

It also explains why combination therapy often works better than single treatments

This approach includes inhibiting transporters and key metabolic enzymes to reduce nutrient uptake and utilization, as well as decreasing the production and release of metabolites such as lactate to remodel the TME